Translational Data Platform

The Translational Data Platform (TDP), developed by Andrew Blake, enables Oxford researchers to fully capitalise on patient clinical data, imaging and molecular data generated from samples collected during clinical studies. The TDP is part of the Oxford ECMC and is key to its mission to integrate research science with early-phase clinical trials.

Data from clinical trials and grant programmes including single cell and bulk RNASeq expression data, NGS mutations, SNPs, copy number, methylation, proteomics, IHC scores and images, H&E images, MRI and other scans, clinical data, and outputs of machine learning image analysis algorithm models are combined into a single, secure, user-friendly, multi-omic data platform: cBioportal. Patient-identifiable information is removed by our team to create a central point for rigorous analysis and interpretation.

The TDP was successfully validated in the S:CORT trial, where it allowed for the integration of image-based analyses with clinicopathological outcomes, gene expression and methylation results. This enabled the classification of over 2000 patients with newly diagnosed colorectal cancer into one of the four Consensus Molecular Subtypes (CMS).

Over 800 colorectal patients (S:CORT), 250 oesophageal cancer patients (SCOPE) and 40 breast cancer patients (FRONTIER) are already on the platform, and new trials will be added regularly. To request access to this data please fill out this form and email it to sara.danielli@medsci.ox.ac.uk"

Legend: Example of data flow through the Translational Data Platform – The DeLIVER study

The TDP aim is to help Oxford University or OUHFT-based cancer researchers and clinicians to conduct hypothesis-generating research.

To request the TDP help with your clinical data management please complete this form and email it to andrew.blake@oncology.ox.ac.uk or sara.danielli@medsci.ox.ac.uk