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Oxford's Colorectal Cancer Stratified Medicine Network

Colorectal cancer (CRC) remains the second most common cause of cancer death, and patients with stage 3/4 cancers at diagnosis only have a 10% survival rate at 5 years.

CRC presents an opportunity for precision medicine as it is common cancer, has known and established driver molecular pathways, and pre-treatment molecular stratification is achievable.

ACRCelerate brings together a European-wide consortium of researchers at the forefront of CRC research. Researchers Prof Simon Leedham and Prof Tim Maughan lead the work from Oxford, collaborating with researchers across the UK, Italy and Spain.

The overall aim of the consortium is to generate robust and reproducible preclinical data to de-risk future clinical trials based on patient stratification. This will be achieved through:

  • developing preclinical models that recapitulate the molecular subtypes of CRC and characterising their signalling pathways
  • using DNA and RNA sequencing to subtype the models, identify and test new therapeutics
  • integrating data in a bioinformatic analysis pipeline

This research is currently funded by CRUK.

Existing collaborations across the network. The hubs of the network are shown with their existing internal and external collaborationsExisting collaborations across the network. The hubs of the network are shown with their existing internal and external collaborations

This international network prevents proprietary duplication of work, enhances collaboration and training and facilitates result validation.This international network prevents proprietary duplication of work, enhances collaboration and training and facilitates result validation.

Colorectal Cancer News

Crowd-sourcing approach assesses current methods for improved automated detection and boundary mapping of colorectal cancer precursors

A computer vision challenge was set to objectively quantify the generalisability of polyp detection and mapping algorithms, and challenge participants to innovate novel methods.

AI-based method provides insights for predicting colorectal cancer outcomes

The largest multiparameter immunoprofiling study in cancer to date has suggested an underappreciated role of a subset of immune cells in determining the risk of bowel cancer relapse after surgery.

What Matters Most to people with colorectal cancer? Oxford Cancer to host workshop on patient priorities.

Oxford Cancer is committed to supporting research that responds to the needs of people with cancer. We are working with groups of patients with different cancers to identify the ‘Top Ten’ issues that matter most to them. These lists of priorities will be shared with our research colleagues.