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A brightly coloured histopathology scan. Specific cells are highlighted.

The Translational Histopathology Laboratory (THL) is based in the Old Road Campus Research Building next to the Churchill Hospital. It specialises in tissue handling and processing, including histochemistry, immunohistochemistry (IHC), multiplex Immunofluorescence (IF), RNAScope and computer-aided analysis of digitised slides. The lab is supported by funds from the NIHR/BRC and CRUK. It is led by Dr Sarah Blagden (Oncology) and Dr Alistair Easton (Pathology).

The THL provides support to biomedical research groups across the University as well as external, commercial, partners. It works in basic and translational research to develop IHC based assays on both mouse and human tissue. There is a strong focus on translational work, clinical trials and preclinical biomarker identification. We aim for the translation of research into clinically accredited and deployable, GCP compliant, validated assays.

The facility is available as a core service to any Oxford University or OUHFT based cancer researcher for the following:

Our Team

We can turn your fixed tissue into FFPE blocks and slides – ready for your research!

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View the overall structure and distribution of cells in your tissue samples with H&E staining

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We will optimise a protocol to get your antibody staining looking the best it can

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Observe antigens of interest in your tissue samples with single or double chromogenic IHC

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Tired of looking down the microscope? Digitise your slides and automate your analysis

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View multiple tissue samples on one slide with a TMA

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Visualise RNA biomarkers with chromogenic or fluorescent detection using RNAscope

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Visualise multiple markers at once with our multi-plex IF workflow

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Use HALO for faster and easier analysis of markers in your brightfield and fluorescent images

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The THL lab is supported by funding from:

Oxford Cancer, University of Oxford, ECMC, Oxford University Hospitals Trust, NIHR logos.