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In 2019, NuCana approached Oxford cancer researchers for clinical positioning input. They were supported from an initial 68 patient PK profiling study which was followed by combination studies and studies testing 2nd/3rd generation agents. In parallel mechanistic research was undertaken at the University that lead to the development of a companion diagnostic assay which was subsequently published and integrated into studies to help identify early signs of efficacy. Subsequently Nucana has gone on to launch an international registration phase 3 trial and is valued at IPO at $463M.