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Chemotherapy remains one of the more common treatment options for cancer patients. By understanding more about fundamental cancer biology, we can identify tumour weaknesses to exploit through targeted therapies. Translating these opportunities into drugs is a lengthy and expensive process that involves a range of scientific disciplines including target identification and structure determination, medicinal chemistry and lead optimisation, high-throughput screening and toxicity prediction. New techniques that improve the efficiency and accuracy of these processes are being developed across Oxford to enable more effective drugs to be developed faster and at a lower cost.