Identification of cancer epitope targets
- Collaborators: Tim Elliott, David Church, Andrew McMichael, Ricardo Fernandes, Nicola Ternette, Hashem Koohy, Michael Dustin, Paresh Vyas, Ahmed Ahmed
- Challenge: Inducing tumour-specific immunity and preventing escape
Based on our research into mechanisms of antigen processing in tumours, Oxford researchers are identifying candidate tumour vaccine epitopes that are optimal for T cell activation, resistant to escape from cancer mutations, and epigenetic changes targeting the antigen processing pathway and less prone to induce T cell exhaustion. In work linked to the Cancer Big Data theme, and leveraging Oxford spinout SingulaBio, we will develop better algorithms to predict antigenicity and immunogenicity of tumour antigens to inform adoptive T cell therapy in ovarian cancer, CAR-TcR therapy in AML and for vaccine design in multiple cancers.