Application of topological data analysis to clinical trials
- Collaborators: Xin Lu, Helen Byrne, Heather Harrington
- Challenge: Making the integration of computational biology in cancer research routine
Oxford researchers are applying topological data analysis to deep phenotyping ‘omics and clinical data derived from patient receiving experimental therapies, for example, oesophageal cancer patients receiving a combination immunotherapy and chemo/radiotherapy. By interrogating multifaceted data from small clinical trials Oxford researchers are providing an agile and adaptive framework for identifying new biomarkers, stratifying patient response, and informing the development of improved treatment strategies at a patient-specific level.