Data generated by the THL now meets internationally recognised quality and traceability standards, a key step towards enabling more translational studies to move confidently from discovery to the clinic. GCLP accreditation also allows the THL to deliver analyses contributing to primary and secondary clinical trial endpoints.
The THL provides a comprehensive range of histopathology and digital pathology services, including:
- Tissue processing, embedding, and sectioning
- Haematoxylin and Eosin staining
- Antibody optimisation and single or double chromogenic IHC
- Slide scanning, automated tissue segmentation, and scoring
- Tissue microarray construction
- Multiplex immunofluorescence (5x colours panel) and imaging
- Digital image analysis using the HALO® platform
Alongside technical capability, the THL offers researchers access to pathology and digital pathology expertise. Dr Alistair Easton, pathologist and Senior Clinical Researcher in the Department of Oncology, is available to answer questions related to staining, tissue architecture and digital pathology analysis.
THL staff can advise on study design, antibody optimisation, and analysis strategies, helping researchers and clinicians obtain robust, reproducible data for both exploratory and regulated studies.
The ability to spatially interrogate markers on multiple samples has been game-changing for us, resulting in new scientific and clinical insights and the development of potential novel diagnostic tools. Without the support of the THL we would not have been able to generate such impactful data
Eileen Parkes, Associate Professor, Innate Tumour Immunology.
The THL’s combination of accredited laboratory processes, expert pathology input, and advanced image analysis tools provides a unique resource within the Oxford research ecosystem. Whether supporting early-stage biomarker discovery or regulated clinical trials, the laboratory works closely with investigators to optimise protocols, standardise methods, and accelerate translational progress.
Researchers interested in discussing potential projects or seeking advice on pathology workflows are encouraged to contact the THL team to explore how the facility can support their studies.