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Remodelling the tissue immune microenvironment (TIME) during tumour development

  • Challenge: Expanding the immuno-oncology footprint

Oxford researchers are investigating the evolution of the three-way conversation between cancer cells, stromal elements and immune cells from before the first immune-sensing events in precancerous states, during tumorigenesis, and under therapeutic pressure. By analysing clinical samples, murine models (in partnership with the collaborators at Glasgow and Edinburgh) and complex co-culture systems, they aim to discover the TIME contexts predictive of response in GI cancers and understand why CD8+ infiltration is not universally predictive of therapeutic response nor prognosis.